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In the study, normal mice with a muscle injury received steroids just before injury and for two weeks after the injury, and then they were treated with a chemical drug once a day for two weeks. They were treated with the drug the same way as the injured mice, and they learned to avoid the drug area. The steroid and chemical were given by placing a catheter through the leg and into the thigh muscle, just below the knee. They were given the chemical over the course of eight weeks in a four-week period to see whether steroids work like the chemical, and whether it really improves recovery. They found the steroid really did increase recovery by 50 percent in the muscle and by 30 percent in the muscle fibers. "This study showed that steroids were effective to restore muscle protein synthesis in the injured area, and so long as the steroids were not administered with other substances, there was a significant effect," said Dr. David S. Katz, a co-author of the study and professor of radiology and surgery at the Icahn School of Medicine at Mount Sinai, in New York. "We found that the most profound effect was after seven weeks. The drug did not influence the recovery of muscle protein synthesis." The research revealed a surprising phenomenon -- a drug that helps boost recovery may not do so at all. Katz said the researchers had the impression that steroids might have a positive effect, because they had observed significant improvement in recovery after giving steroids only to the injured mouse. He and his colleagues were not aware that steroids could affect recovery, according to Katz. The research is one of two recent reports by researchers at the Icahn School and from the Department of Radiology and Ultrasound in the Icahn School of Medicine and its companion department at Mount Sinai, reporting in the journal Science. Related Article: